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Week 6 TNF: 49ers-Seahawks Preview, Props & Prediction

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San Francisco 49ers vs. Seattle Seahawks: Week 6 Preview & Betting Insights

The San Francisco 49ers travel to face the Seattle Seahawks to kick off Week 6 of the NFL season. Both teams are coming off surprising losses, looking to regain momentum. A win would be crucial for the 49ers (2-3), as it would bring them level with the Seahawks (3-2), who started strong with a 3-0 record but have since stumbled with back-to-back losses. The stakes are high in this divisional matchup, which could have long-lasting implications in the competitive NFC West.

The 49ers are favored by 3.5 points at BetRivers, and they’ve received significant backing, with 77 percent of the money wagered on the spread line supporting San Francisco. On the moneyline, their -190 odds have attracted 76 percent of total bets, accompanied by 85 percent of the money. It seems bettors have strong confidence in the 49ers despite their recent setbacks.

The Over/Under is set at 49.5 points, and the Over has garnered significant action, with 76 percent of the money backing that outcome. History favors this bet, as six of Seattle’s last eight home games have hit the Over. However, Seattle has failed to cover the spread in seven of their last eight games, adding another layer of unpredictability to this contest.

  • San Francisco has covered the spread in four of their last five games against Seattle.
  • The 49ers have also won the first half in seven straight games against NFC West opponents.
  • Seattle’s defense has allowed an average of 128 rushing yards per game, which could spell trouble against the 49ers’ strong run game.
If you're looking for expert analysis on the 49ers and Seahawks matchup, check out NFL Betting Tips for more details.

Prop Bet: Jordan Mason Anytime TD

One of the most popular prop bets is for Jordan Mason to score a touchdown anytime during the game. At -220 on BetRivers, Mason has become a favorite, accounting for 2.8 percent of all prop bets. The bet makes sense given Mason’s production—he has three rushing touchdowns this season—and the Seahawks’ recent struggles stopping the run. Seattle has been gashed by the run in consecutive losses, and this could be a pivotal factor on Thursday night.

Key Stat: 49ers’ Dominance Over the Seahawks

The 49ers have dominated this rivalry recently, winning the last five meetings, including a victory in last year’s playoffs. More impressively, San Francisco has managed to seize control early, leading at halftime in seven consecutive games against NFC West rivals. This strong start often allows them to dictate the pace of the game, controlling both the clock and the momentum.

Latest News: Seahawks Struggling to Find Offensive Balance

While Seahawks QB Geno Smith leads the NFL in completions (143) and passing yards (1,466), Seattle has been heavily reliant on the passing game. Smith has thrown for at least 284 yards in four straight games, but Seattle’s inability to establish the run is becoming a glaring issue. In their loss to the Giants, running backs Kenneth Walker III and Zach Charbonnet combined for only seven carries.

Seattle has thrown the ball on 67.4 percent of their plays, the highest in the league. This imbalance has made their offense predictable, and teams are now better equipped to defend the pass. Head coach Mike Macdonald acknowledged that the team needs to prioritize the run:

“We all know we need to run the ball more. Our opponents know it. Our players know it. We have to create more situations where we can run it effectively.”

The Seahawks’ offensive struggles are mirrored by their defense, which has allowed over 128 rushing yards per game. If they can’t plug these gaps, the 49ers’ run-first offense could take control of this game.

49ers Looking to Rebound Without Christian McCaffrey

The 49ers are also dealing with significant challenges, particularly on offense. Without star running back Christian McCaffrey, who is sidelined with Achilles tendinitis, San Francisco’s offense has struggled in the red zone. They currently rank 29th in the NFL, scoring touchdowns on just 40.9 percent of red-zone drives, a steep drop from their league-best 68 percent last season. McCaffrey’s absence has been felt deeply—he was the reigning NFL Offensive Player of the Year, scoring 18 red-zone touchdowns in 2023.

San Francisco’s young quarterback, Brock Purdy, recognizes the need to find their offensive rhythm:

“We’re a few plays away from really gelling. I’m confident we’ll find it, but we need to start playing complementary football.”

The 49ers’ ability to adapt without McCaffrey will be tested against a Seahawks team desperate to stop their slide.

To learn more about the handicappers and betting trends for this week, head over to Picks to Win More NFL Props

Injury Report: Major Absences on Both Sides

The injury bug has bitten both teams, which could play a crucial role in how this game unfolds.

  • 49ers: Kicker Jake Moody (ankle) is out, along with safety Talanoa Hufanga (wrist), defensive tackle Jordan Elliott (knee), and linebacker Demetrius Flannigan-Fowles (calf). Cornerback Charvarius Ward (knee) and wide receiver Chris Conley (oblique) are questionable.
  • Seahawks: Defensive tackle Byron Murphy II (hamstring), cornerback Tariq Woolen (ankle), and linebacker Uchenna Nwosu (thigh) are out. Linebackers Boye Mafa (knee) and Derick Hall (foot) are questionable, alongside safety Julian Love (hamstring).

These injuries, especially on Seattle’s defensive line, could make it even harder for the Seahawks to stop San Francisco’s run game, further tilting the balance in favor of the 49ers.

Prediction: 49ers Will Control the Tempo

Both teams are in need of a bounce-back performance, but the 49ers appear better positioned to execute their game plan. With a banged-up Seattle defense and a run game that hasn’t found its footing, San Francisco should be able to control the line of scrimmage and dominate time of possession. The Seahawks, while talented, are overly reliant on Geno Smith’s passing abilities, and without a reliable run game to balance things out, the 49ers’ defense may prove too tough to overcome.

Prediction: 49ers 27, Seahawks 20.